Pep Guardiola’s men are two points adrift of leaders Liverpool with a game in hand, meaning victory here would put them in firm control of the title race with just three matches left to play.
Having won each of their last 10 successive league games, they are priced at just 4/9 (1.44) with bet365 to move top of the table by coming out on top in their local rivals’ back yard.
The Red Devils have lost six of their last eight fixtures in all competitions, and are hefty 13/2 (7.50) outsiders to strike a major blow to their guests’ title bid with a shock win, or 4/1 (5.00) to even hold them to a draw.
Luke Shaw is available once again following suspension, while Ander Herrera could also be in contention after returning to training following injury.
Kevin De Bruyne is unlikely to feature after coming off injured in Saturday’s victory over Tottenham, with Claudio Bravo the only other injury absentee for the guests.
While this clash may previously have been pinpointed as the most likely stumbling block standing between the Citizens and the title, it is hard to see them failing to collect maximum points on current form.
Ole Gunnar Solskjaer’s men come into this match on the back of a 4-0 thrashing by Everton at the weekend, the latest in a string of disappointing performances that has seen them concede 16 goals and score just six over the last eight games.
Having run out convincing 3-1 winners in the reverse encounter back in November, odds of 11/10 (2.10) seem generous on City winning by at least two goals against a beleaguered United.
All odds correct at time of publish. Please gamble responsibly.