Pep Guardiola’s men are averaging almost four goals a game in front of their own fans this season, and are spearheaded by Sergio Aguero who has scored 11 times in his last 11 appearances.
However, Aguero is not the only player full of confidence in the home attack, with Raheem Sterling having scored a 14-minute hat trick in the 3-1 victory over Watford at the weekend.
Also on target in the first leg to make it three goals in two Champions League games, Leroy Sane is available at a slightly more generous 21/20 (2.05) to come back to haunt his club once again.
At the other end of the pitch, Domenico Tedesco may look to the fit again Breel Embolo as his side attempt to overturn the first-leg deficit.
The Switzerland international struck twice against Werder Bremen on his first start since November following injury, and can be backed at 20/1 (21.00) to make an impact once again with the opener, or 11/2 (6.50) to strike anytime.
Embolo’s return is particularly welcome given he remains the Konigsblauen’s top-scoring striker despite the injury, with Marko Uth inspiring little confidence at 9/2 (5.50) anytime odds after scoring just five times in 28 games.
In fact, Nabil Bentaleb is Schalke’s top scorer with eight goals in all competitions – all from the penalty spot – and may represent their best bet at generous 6/1 (7.00) to add to his three goals in the last two Champions League matches.
Odds correct at the time of writing. Please gamble responsibly.