Lyon president Jean-Michel Aulas said the Ligue 1 side will not stand in the way of Alexandre Lacazette and his desired departure.
Frequently linked with a move to a European giant, Lacazette talked up the prospect of playing for reigning La Liga champions Barcelona after confirming he wants to leave Lyon at the end of the season.
Lyon turned down a bid from Arsenal in August but Aulas insisted the French outfit are willing to grant the 25-year-old forward's wish.
"If one day there is an opportunity, of course, as we did with [Samuel Umtiti] and [Eric Abidal] in Barcelona or Karim [Benzema] in Madrid or further in time with [Ludovic Giuly] to Monaco, who left, why not?" Aulas told OL TV.
"Alex has wanted to play in a great club and Lyon does not object. We are perfectly in line."
Lacazette has enjoyed another prolific season for Lyon, scoring 18 goals in 17 league matches.