A home game against Wolves is the reward for the victors and Klopp, expecting his players to face another spirited defensive display at Home Park, urges his side to repeat the performance that saw them lead United for most of the game in their 1-1 draw on Sunday.
"I heard a lot of things after the game but it was really a concentrated defensive performance and we could not come through, so all the credit for Plymouth," the German told reporters.
"I do not know if the plan from the first second was to be that deep or not but it is up to us to do something about it. We cannot wait until they do something and try to make a counterattack. There are possibilities to speed up the game but we did not use them in the first game. We spoke already about it and the game will be different.
"We have to do what we did to Manchester United, to cool the atmosphere down with the way we play. That is what our main target is for this game.
"We cannot react to what they do. They are allowed to defend with all they have because we are a Premier League team and they are a League Two team.
"Usually, they play differently; they are a top team in League Two. But to go to the next round, as a lower-league team, you should concentrate on defence. That absolutely makes sense. If they open the space, we will take it, but I do not expect it."