Steven Gerrard's reign as Rangers manager began with a 2-0 win against FK Shkupi in Europa League qualifying last week.
The Scottish side were comfortable winners at Ibrox and, after James Tavernier's late penalty afforded the 'Gers some breathing space, Gerrard's men will be confident of completing the job in Skopje on Tuesday.
The 'Gers, however, will have horrendous memories from last term of when Progres Niederkorn of Luxembourg overturned a 1-0 first-leg deficit to send Rangers crashing out of this competition at the first hurdle.
Shkupi will hope that it is their turn to heap misery on the men from Glasgow and bet365 go 13/2 (7.50) that the Macedonian minnows claim a famous victory.
Teenage winger Glenn Middleton came off the bench to make his Rangers debut last week and will hope to make his first start.
Jamie Murphy is again expected to lead the line, having opened the scoring for Gerrard's side in Glasgow on Thursday night.
Temperatures are set to soar in the Macedonian capital and the Scottish side must show that they can cope with the testing conditions.
Gerrard's men found goals hard to come by in Glasgow and the stage could be set for another low-scoring tie on this occasion.
The odds compilers offer 27/20 (2.35) for fewer than three goals to be scored in Skopje and, with Rangers determined to protect their first-leg lead, it is a price that could prove popular with punters ahead of Tuesday's tussle.
Odds correct at time of writing. Please gamble responsibly.