But Fabregas has been named in the starting lineup against Everton alongside Pedro, who is fit enough to feature from the get go after starting on the bench against Spurs at Wembley.
Tiemoue Bakayoko and Andreas Christensen have dropped to the bench for Fabregas and Pedro, while there is still no place for Eden Hazard as the forward continues to recover from an ankle problem.
Everton, on the flip side, have been able to recall Sandro from injury, while Idrissa Gueye has been declared fit enough to start after missing his side's 1-1 draw at Hajduk Split on Thursday.
Dominic Calvert-Lewin, who impressed during the Toffees' 1-1 draw at Manchester City on Monday, drops to bench for Sandro, while Morgan Schneiderlin misses out through suspension.
Gylfi Sigurdsson has also been handed his first Premier League start for Ronald Koeman's side following his big-money summer move from Swansea City.
Chelsea XI: Courtois; Azpilicueta (c), David Luiz, Rudiger; Moses, Fabregas, Kante, Alonso; Willian, Morata, Pedro.
Chelsea subs: Caballero, Christensen, Tomori, Bakayoko, Kenedy, Musonda, Batshuayi.
Everton XI: Pickford, Baines, Jagielka (c), Williams, Keane, Holgate, Davies, Gana, Sigurdsson, Rooney, Sandro.
Everton subs: Stekelenburg, Lennon, Martina, Besic, Calvert-Lewin, Lookman, Kenny.