The Indomitable Lions, Africa Cup of Nations winners earlier this year, crashed to a 2-0 defeat against Chile after conceding twice inside the final 10 minutes on Sunday, before the Socceroos suffered a 3-2 reverse at the hands of a second-string German side on Monday evening.
As a consequence, both nations go into this match knowing that defeat will almost certainly mean an early exit from the competition - with Chile and Germany also due to meet in Group B on Thursday.
Ange Postecoglou's men battled hard against Die Mannschaft but, in the end, Australia did not have enough quality to take a precious point from their meeting with the 2014 World Cup winners. The Socceroos are chalked up as an 11/5 (3.20) chance with Betfair Sportsbook to breathe fresh life into their campaign with a win in this one.
Cameroon barely laid a glove on Chile and the African champions know that they must do more in this game if they are to keep their Confederations Cup dreams alive. Hugo Broos' men can be backed at 13/10 (2.30) to claim a vital victory, with 23/10 (3.30) that the match ends in stalemate - an outcome that is extremely unlikely to be of use to either nation.
With so much at stake, there is plenty of potential for an open and entertaining contest.
Cameroon will surely take heart from Australia's poor defensive record, for Postecoglou's men have shipped seven goals in their last two games and have conceded in seven of their last eight outings. Betfair Sportsbook offer 6/5 (2.20) that Cameroon capitalise on any Australian defensive frailty by scoring more than a single goal in this game.
The Socceroos, however, will feel that they are more than capable of testing Cameroon's resolve having twice found the net against Die Mannschaft in Monday's match and Betfair Sportsbook offer 7/4 (2.75) that Postecoglou's team score more than one goal against the African champions.
There is 3/4 (1.75) that there are goals at both ends and, with these two teams desperate for a positive result, that particular play may prove popular with punters in what could be an open contest.
Better value, however, appears to lie in the 10/11 (1.91) quote for more than two goals to be scored in this game - the selection would have landed in each of Australia's last three games and, at 10/11 (1.91) , it could represent decent value for punters again ahead of Thursday's tussle.