Tusker will host Batoto ba Mungu at Kenyatta Stadium with keeper Duncan Ochieng' expected to make the short trip to Machakos.
Ochieng' missed the brewers 0-0 draw with Thika United last weekend after picking an injury in a 1-0 defeat at the hands of Ulinzi Stars two weeks ago.
The veteran goalkeeper resumed training on Tuesday after sitting out for close to a week. Meanwhile, Lloyd Wahome and Amos Asembeka are still in the rehab and are likely not to make the trip.
The Brewers are yet to win a match since February 14, 2-1 win over Nzoia Sugar.
Sam Timbe played out to a 0-0 draw with Gor Mahia before losing by a solitary goal to Ulinzi Stars only to be held to yet another draw by Thika United last week.
Tusker are four points and six places behind Sofapaka, who are seventh on the log with 10 points.