The visitors are 5/4 (2.25) favourites to record back-to-back European wins over Murad Musaev's men and a draw - which would also see the La Liga side through to the quarter finals - is 12/5 (3.40) with the same firm.
Krasnodar will feel they have a solid chance of qualification on home soil, despite the bookmakers ranking them as 9/4 (3.25) outsiders.
Valencia boast the second-best defence in La Liga this season, but their recent away days have been high-scoring clashes. The visitors' previous six league games on the road have seen both teams score and the last top-flight clean sheet they kept was in mid-November.
Conceding to Barcelona at Camp Nou is no surprise of course, but teams such as Leganes, Celta Vigo and Girona - all of whom sit in the bottom half of the table - have breached the Valencia backline in recent weeks.
That will surely give plenty of hope to a home side that know only a win is good enough to see them through to the quarter finals.
At 3/4 (1.75), both teams to score looks well worth support here with 888Sport. Krasnodar have seen this selection pay-out in four of their last five games in all competitions.
What's more, BTTS has proved correct in three of the Russian's Europa League games at home this season.
The fact that the hosts need to force the issue in the final third should lead to another open game and goals at both ends makes plenty of appeal given Valencia's issues at the back in recent weeks.