Die Werkself are the form team in Germany, having finished the winter season on a 12-match unbeaten streak.
Having not lost any of their last five home matches against this opposition, they are available at 3/1 (4.00) with Betfair Sportsbook to maintain their strong form with a shock victory here.
However, Jupp Heynckes' team are 11 points clear at the top after winning nine out of 10 league matches since his return in October, and are clear 5/6 (1.83) favourites to come out on top against his former club.
Four of the last five encounters between these sides at this ground have resulted in draws, and you can get odds of 3/1 (4.00) on them cancelling each other out yet again in this one.
Heiko Herrlich has a full squad to choose from, while his opposite number is hoping Joshua Kimmich will recover from illness in time to avoid joining long-term injury absentee Manuel Neuer on the sidelines. Crucially, Robert Lewandowski and Mats Hummels are both ruled out of the game.
Leverkusen Strong Head-to-Head
While they have looked unstoppable since Heynckes took over from Ancelotti, the leaders will have marked this fixture as one of the toughest in their domestic calendar.
Die Roten have only left this ground with a victory once in the last 10 visits, suffering three defeats against their bogey team in that period.
Having gone five matches without losing in normal time against Bayern, the hosts will certainly feel confident of causing another upset given their excellent current form.
As well as remaining unbeaten in 12 league matches - a run that includes fixtures against every top six side - they recorded an impressive 1-0 cup win away at Borussia Monchengladbach in their final game of 2017.
Tips and Predictions
All in all, even odds (2.00) seem generous on Leverkusen extending that unbeaten run by avoiding defeat against the depleted champions once again on Friday.