The Gunners are currently sixth in the table, three points behind Tottenham and four away from Liverpool in fourth spot as they seek victory over Roy Hodgson's improved side.
Arsenal were booed off at Selhurst Park last season as they lost 3-0 and saw their European aspirations dissipate amidst away supporters singing 'You're not fit to wear the shirt.'
"What we want is to stop conceding goals, stop missing chances, but as well I want them all to continue to play with the same spirit, the same determination and the same love of the game," said Arsene Wenger ahead of the game.
The 3-3 draw against Liverpool last week was a further example of Arsenal's strength of character but it once again showcased their defensive vulnerabilities as they were hit on the counter attack by Jurgen Klopp's men - something they'll be desperate to avoid on Thursday.
Nacho Monreal has been ruled out after sustaining an inury against Liverpool, while Olivier Giroud and Aaron Ramsey are also sidelined.
"Monreal I would say hopefully 10 days, Giroud as I said before is four to six weeks, but he is a quick healer so I am hopeful he will be less. Ramsey should be back at the beginning of January," confirmed Wenger.
Spanish midfield maestro Santi Cazorla remains a long-term absentee with an Achilles injury.
Arsenal have no players suspended for this game.
ARSENAL POTENTIAL STARTING LINE-UP
Wenger is likely to stick with the bulk of the team that drew against Liverpool last week, with Ainsley Maitland-Niles, Laurent Koscielny, Shkodran Mustafi and Hector Bellerin expected to make up the defence.
Jack Wilshere will continue his partnership with Granit Xhaka in the centre of midfield due to Aaron Ramsey's absence, while Alex Iwobi could support the triumvirate of Alexis Sanchez, Mesut Ozil and Alexandre Lacazette.
The decision over who will play left-back is understood to be related to which formation the Gunners deploy, with Maitland-Niles favoured over Sead Kolasinac when Wenger fields four at the back.
CRYSTAL PALACE TEAM NEWS
Palace boss Roy Hodgson has taken 18 points from 12 games to guide the Eagles to 16th place, just two points above the relegation zone after taking over with the side bottom of the table.
Christian Benteke returns for the game against Arsenal after he was suspended for the game with Swansea, but Mamadou Sakho misses out with a calf strain and Joel Ward is also a doubt with a groin problem.
James McArthur is the club's top scorer with 4 goals to his name so far this season.
BEST OPTA MATCH FACTS
Crystal Palace have won only one of their last 12 home league games against Arsenal (D5 L6), though it was a 3-0 victory in this exact fixture last season.
Arsenal have only failed to score in two of their last 19 league games against Crystal Palace – the 0-3 loss last season and a 0-0 draw at Selhurst Park in October 1997.
After losing their first three home league games of the season without scoring, Crystal Palace are unbeaten in their last six at Selhurst Park (W3 D3 L0) and have scored exactly two goals in each game.
Arsenal have only won two Premier League away games this season – their joint-fewest tally after nine away games of a campaign in the Premier League era (level with 1994-95, 1998-99, 2000-01 and 2005-06).
Arsenal have kept a clean sheet in all three of their Premier League London derbies this season – they haven’t gone four London derbies without conceding since February 1999.
Mesut Özil has had a hand in nine goals in his last 10 Premier League appearances for Arsenal (four goals, five assists).
Arsene Wenger will take charge of his 810 th game as a Premier League manager in this match; equalling Sir Alex Ferguson’s Premier League record.
TV COVERAGE & KICK-OFF TIME
The match is being televised on Sky Sports in the UK, while in the United States (US) Crystal Palace v Arsenal can be watched live and on-demand with fuboTV (7-day free trial).