Pepi appeared at the prematch press conference with Bosz, claiming he is excited for the opportunity ahead of him.
"Of course it's a wonderful game to play, but whatever my role is, I will always be there," Pepi said. "I'm ready for the chances I get and it's up to me to take them."
PSV enters the match sitting 19th in the Champions League standings with 11 points through seven games. Pepi will of course feature, but USMNT teammates Malik Tillman and Sergino Dest are injured, and will not play as a result.
U.S. international Richard Ledezma, meanwhile, is likely to make a cameo after a burst into the XI in recent weeks under Bosz. Ledezma last appeared for the USMNT in 2021.
Pepi added that although minutes have not come easy this season, he has held his head high and is ready to play once called upon.
"Of course it's difficult sometimes," the striker added. "But it's up to me to stay professional. I'm lucky I have a controlled character, which helps in my situation."