United's poor form has seen them slip five points behind fourth-placed Tottenham and Enrique does not see a route for the club to qualify for the Champions League.
The Spaniard added: "I think he has lost the dressing room. I'm not sure how long Manchester United will keep him for but I don't think they have any chance of making the top four this season. The players should still go out and perform regardless, but it's true that when you like the manager you play better for them. You want to win for them as well as for yourself and the fans."