Jurgen Klopp's men won 7-0 against Maribor in a record-breaking performance on the same night as Spurs held on in the Bernabeu, and are looking for points in the top-flight.
While Spurs are well amongst the runners and riders - they sit third - Liverpool are eighth, nine points behind leaders Manchester City.
|Game||Tottenham Hotspur v Liverpool|
|Date||Sunday, October 21|
|Time||16:00 BST / 11:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the game will be available to watch live on television on Sky Sports Main Event, as well as Sky Sports Premier League. It will be available to stream live on the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports Main Event / Sky Sports Premier League||Sky Go app|
In the US, viewers can watch the game live on television on NBCSN and it will also be available to stream online using the NBC Sports app. It can also be followed on the Spanish-language channel NBC Universo.
|US TV channel||Online stream|
|NBCSN / Universo||NBC Sports app|
SQUADS & TEAM NEWS
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Aurier, Trippier, Alderweireld, Vertonghen, Sanchez, Foyth, Davies, Rose|
|Midfielders||Dembele, Dier, Eriksen, Lamela, Nkoudou, Sissoko, Wanyama|
|Forwards||Kane, Llorente, Son|
Spurs are likely to be without Mousa Dembele, who suffered a fresh injury setback this week, while Ben Davies may have recovered from illness to take part.
Victor Wanyama and Erik Lamela are certainly out, but Georges-Kevin Nkoudou returns to contention, along with Danny Rose, who made a cameo appearance against Real Madrid.
Potential Spurs starting XI: Lloris; Sanchez, Dier, Alderweireld; Trippier, Alli, Winks, Vertonghen; Eriksen, Son; Kane.
|Goalkeepers||Karius, Mignolet, Ward|
Lovren, Gomez, Klavan, Moreno, Matip, Flanagan, Alexander-Arnold, Robertson
Wijnaldum, Milner, Coutinho, Henderson, Grujic, Mane, Can, Markovic, Woodburn, Oxlade-Chamberlain
|Forwards||Salah, Solanke, Firmino, Sturridge|
Sadio Mane will miss the game with a hamstring injury, while Adam Lallana also remains on the sidelines.
Defender Nathaniel Clyne and goalkeeper Adam Bogdan are both long-term absentees.
Potential Liverpool starting XI: Mignolet; Gomez, Matiz, Lovren, Moreno; Can, Henderson, Milner; Salah, Coutinho, Firmino.
BETTING & MATCH ODDS
Spurs are marginal favourites to win at home at 6/5, according to dabblebet, with Liverpool rated at 9/4. The draw is priced at 5/2.
Spurs have a woeful record against Liverpool, and are winless in their last nine games against the Reds.
However, their recent form is something to build on - they are now 10 games unbeaten in all competitions, and will hope to keep the pressure on the two Manchester clubs at the top of the table with a victory over Jurgen Klopp's men, whose own form has been somewhat patchy.
In the league this season, the Reds have won just three times, but they have a platform from which to take off following their record-breaking victory in Europe.
With two high-pressing teams going at it, this one is a truly mouthwatering Premier League clash.