Spurs were beaten 2-1 by Chelsea last time out, extending their woeful record at the national stadium.
Mauricio Pochettino's men have won just once at the ground in the last two seasons - in a Champions League match against CSKA Moscow - but will have their eyes on three points against Sean Dyche's Burnley.
Kieran Trippier is fit to play against Burnley after returning to the fold against Chelsea, but Georges-Kevin N'Koudou remains injured, with a foot injury.
Danny Rose is also sidelined with knee ligament damage, and Erik Lamela is still out due to a hip injury.
Club-record signing Davinson Sanchez, secured from Ajax, is yet to receive a work permit from the UK government, but the club are reportedly confident that will be sorted in time for him to play against Burnley.
No Tottenham player is suspended for the clash with the Clarets, with Dele Alli's ongoing three-match ban only valid for European competition.
TOTTENHAM POTENTIAL STARTING LINE-UP
Spurs's formation may depend upon whether Davinson Sanchez receives his work permit in time for the game.
Mauricio Pochettino has successfully experimented with a back three in recent months, and Sanchez would likely slot into the middle, alongside fellow former Ajax stars Toby Alderweireld and Jan Vertonghen.
If not, both Alderweireld and Vertonghen are likely to play at centre-back, with Kieran Trippier - fit again - and Ben Davies at full-back.
Victor Wanyama was out of sorts against Chelsea but he is likely to have returned to full match fitness, and is set to partner Mousa Dembele in midfield. If Pochettino opts against picking the Kenyan, Eric Dier will play in a central position.
Heung-Min Son is set to return to the first-team, while Christian Eriksen and Dele Alli will provide support to lone striker Harry Kane.
BURNLEY TEAM NEWS
Burnley ruled the back pages on the opening weekend of the season, as they managed to do what Tottenham couldn't and beat Chelsea at Stamford Bridge.
They were unable to follow that up with a victory, however, as they lost 1-0 to West Bromwich Albion the following weekend. A 2-0 win over Blackburn Rovers in the Carabao Cup in midweek has restored some goodwill however, with Sean Dyche's men hoping to capitalise on that momentum against Spurs.
Dyche will be without summer signing Jonathan Walters, however, who is ruled out with an ankle injury, while Dean Marney is likely to miss out due to a knee ligament problem.
BEST OPTA MATCH FACTS
Tottenham have won four and lost just one of their previous six Premier League meetings with Burnley (W4 D1 L1).
The Clarets’ last league win against Tottenham Hotspur in London came back in October 1974 in the top-flight (3-2).
Harry Kane has now had 34 shots and played 12 games in the month of August without scoring in the Premier League.
TV COVERAGE & KICK-OFF TIME
The match is not being televised live in the UK but will kick off at 16:00 BST. Highlights will be broadcast on Match of the Day 2, which airs at 22:35 on BBC One.