This will be the 55th league meeting between Tshwane's biggest football clubs and both teams are heading into this game in good form.
Matsatsantsa are currently enjoying a six-match unbeaten run in the league having drawn 0-0 with a rejuvenated Bloemfontein Celtic side away in their previous game.
However, the three-time PSL champions have recorded five draws and one victory, which came against Free State Stars last month.
SuperSport are placed fourth on the league standings having accumulated 19 points from 11 games. They are two points behind third-placed Celtic.
|Game||SuperSport United v Mamelodi Sundowns|
|Date||Sunday, December 2|
|Time||15:30 SA Time|
TV Channel, Live Score & How To Watch
In South Africa, the game will be shown live on SuperSport 4. You can also catch live updates on Goal.com.
|Live Match Centre||TV Channel|
Squads & Team News
Kaitano Tembo will be keen to mastermind a victory over the Brazilians which would see his side keep up with the pacesetters in the race for this season's PSL title.
Matsatsantsa will be without three key players in Thabo Mnyamane, Bradley Grobler and Dean Furman, who are all out nursing long-term injuries.
James Keene and Evans Rusike, who have scored seven league goals between them this season, will look to inspire Matsatsantsa to their maiden league win over Sundowns since 2013.
Meanwhile, Sundowns currently boast the longest unbeaten in the PSL this season having extended their undefeated run to 23 games when they drew 0-0 with Orlando Pirates at home in their previous league game.
The Brazilians are coming off a morale-boosting 2-0 win over Equatorial Guinea's Leones Vegetarianos FC away in a 2018 Caf Champions League preliminary round match in midweek.
They find themselves placed fifth on the PSL standings having collected 18 points from 10 games. The defending champions are three points behind third-placed Celtic.
Pitso Mosimane knows that his side needs to secure a victory in the Tshwane Derby in order to cut the lead at the top of the league standings.
Sibusiso Vilakazi is set to miss the eagerly-anticipated match due to a long-term injury, while Anthony Laffor has been out nursing an injury.
Mosimane will look to Jeremy Brockie, who is slowly regaining his scoring form and the New Zealand hitman will look to haunt his former side.
In head-to-head stats since 1990, SuperSport and Sundowns have met in 54 league matches.
The Brazilians have dominated this fixture, recording 28 wins compared to 14 for Matsatsantsa, while 12 games have been drawn.
Sundowns collected four points from SuperSport last season, winning 2-0 away and drawing 1-1 at home.
They are also enjoying a 10-match unbeaten run in the league against SuperSport.