The latest incarnation of the Steel City Derby takes place on Monday night and it may turn out to be one of the most significant clashes in years.
Chris Wilder's men are real promotion candidates and there is nothing Sheffield Wednesday would love to do more than derail their rivals' charge for the top two.
Despite being at home Sheffield Wednesday aren't fancied by the bookies with odds of 12/5 (3.40) being offered by bet365 on the hosts winning this one. The Blades are favourites to come out on top at 21/20 (2.05) and the draw is priced up at 5/2 (3.50) with the same firm.
Both clubs come into this game with fully available squads with no fresh injury or suspension worries.
Both teams will have had this game marked down on their calendars at the beginning of the season but it now holds so much more importance with how the table currently stands.
Sheffield United are within touching distance of promotion and their fate is in their own hands with just 12 games to go.
Wednesday will be desperate to be the team to halt the Blades' momentum and they are more than capable of doing so in this match.
Although Chris Wilder's men have been in top form, that can sometimes go out of the window in a derby match when so much is at stake and this could be one of the more heated derby matches in the Championship this season.
After over 100 appearances for the Owls, Gary Madine lines up against his former club for the first time in this historic fixture and will hope to get on the score sheet. The 28-year-old is 21/10 (3.10) to find the net at any time.
Predictions and Tips
There could be cards galore in this game, especially if Steve Bruce implements a defensive gameplan to frustrate the visitors. A red card in the match is available to be backed at 3/1 (4.00) and that could be a decent bet given the fierce rivalry between these sides.
The best bet of the week comes in the form of Sheffield Wednesday double chance at odds of 4/5 (1.80), meaning that a victory for the Owls or a draw would see your bet settled as a winner.
The home team are unbeaten in six Championship games and Steve Bruce is somewhat a master of derby fixtures, losing none of his four Second City derbies during his tenure at Aston Villa.
With the added pressure on United due to their promotion bid the match seems perfectly set up for the blue and white side of Sheffield to secure at least a share of the bragging rights in this fixture.
The previous two head-to-head meetings have finished 0-0 and four of the last six clashes have finished in draws. At odds of 4/5 (1.80), opposing an away win looks the way to go on Monday night.
Prices correct at the time of writing. Please gamble responsibly.