It has also proved one of the toughest grounds for Los Blancos to travel to in recent years with, Sevilla winning each of their last three home league matches against them.
Real Madrid remain unbeaten in La Liga under Julen Lopetegui, with four wins and a draw from their opening five games.
Dani Carvajal remains sidelined for Real Madrid at right-back while the European champions are also missing Isco who will be out of action for a month with acute appendicitis.
Sevilla also have injury concerns with defensive players Gabriel Mercado, Sergio Escudero and Maxime Gonalons all likely to be out.
As well, Sevilla have scored in each of their last nine home matches in all competitions against Real Madrid, netting over 1.5 goals in eight of those games.
The hosts are priced at 10/7 (2.43) to score over 1.5 goals on Wednesday and there is every chance that we should consider investing in a high scoring match.
Tips and predictions
The best option for this game however looks to be backing over 3.5 goals at the healthy looking price of 19/17 (2.12).
This bet has paid out in eight of the last ten meetings between these two sides in all competitions and is offered at odds that are too good to turn down given the form of both sides.