Rojo has not featured for United this season due to a knee ligament injury sustained in April, having become a regular in Jose Mourinho's side before the setback.
United only need a point from their next European fixture against Basel to be sure of a place in the knockout stages, and Rojo hopes he can return to the first team once progression to last 16 has been sealed.
"[On Wednesday] I am going to play with the reserves in a friendly match," Rojo told TyC Sports. "I feel good. Up until now, I have not had any problems but training is not the same as a match.
"In three weeks we have a Champions League game and if all goes well tomorrow, I could play in that."
"I have to win my place back in the team so that Jorge Sampaoli considers me for the World Cup," he added.
"I have been out a while but I am determined to get back into the national team. I want to show Sampaoli how good I am."