These two sides met in the quarter-finals of the Copa del Rey last month, with Los Blancos winning 7-3 on aggregate.
Girona are the most out-of-form team in La Liga with Eusebio Sacristan's men having failed to win any of their last ten league games, whilst Real have just won five La Liga games in a row for the first time in 18 months.
The European champions are priced at 1/6 (1.16) with bet365 to record their ninth home league win this term. Girona are 14/1 (15.00) to end their winless run with a first ever victory at the Bernabeu. The draw is offered at 7/1 (8.00).
Watch and bet live on Real Madrid vs Girona
bet365 customers in the UK can watch and bet live on this fixture. Your account be be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Girona have Colombian centre-back Bernardo Espinosa suspended, whilst Seydou Doumbia, Marc Muniesa and Aday Benitez are all likely to be missing.
Real Madrid have the best home defensive record in La Liga, having conceded just five goals in the 11 matches they have contested in front of their own fans.
Indeed, Los Blancos have conceded in only three of those 11 games and Girona's recent record leads us to believe that another clean sheet is on the cards for the hosts.
The Catalans have failed to score in their last three league matches and are extremely low on confidence, not least because yop scorer Cristhian Stuani has failed to score in his last five appearances.
Tips and predictions
Real Madrid to win to nil is priced at 5/6 (1.83) and is a selection which has paid out in five of their six home league games.
The hosts to win with a -2 handicap could also be of interest at 13/10 (2.30), with this bet proving profitable in the two most recent league meetings between these sides.
Odds correct at time of writing. Please gamble responsibly.