The second Madrid derby of the season takes place this weekend at the Bernabeu with the hosts aiming for revenge following defeat in the UEFA Super Cup back in August.
Diego Simeone's side were five points behind their cross city rivals after four matches, yet a win on Saturday night would see them overtake Real Madrid.
Real Madrid have not won a league game at home to Atletico since December 2012 and bet365 price them at 21/20 (2.05) to end that barren streak with a victory on Saturday.
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Real Madrid will be missing Isco after he was operated on for apendicitis. Dani Carvajal has trained this week after missing the last two games and could return although Los Blancos' other full-back Marcelo has been ruled out after picking up a knock in Seville.
Atletico for their part are waiting on the fitness of Uruguayan centre-back Jose Maria Gimenez who went off during Tuesday night's win over Huesca. With other centre-back Stefan Savic also ruled out Simeone could have a problem in the heart of defence if Gimenez is not fit.
Atletico's record at the Bernabeu is extremely impressive and a ground where they used to consistently struggle has become a place they head to with confidence.
In each of the last two seasons in this fixture Real Madrid have taken the lead after a goalless first half only for Antoine Griezmann to equalise and the game to finish in a 1-1 draw.
Last season's meeting at the Estadio Wanda Metropolitano finished in a 0-0 draw and while the UEFA Super Cup meeting last month brought plenty of goals, this fixture tends to be extremely tight.
Tips and predictions
The last three league derbies hosted by Real Madrid have all been goalless at half time and a repeat is priced at an attractive looking 2/1 (3.00). Under 2.5 goals meanwhile has paid out in five of the last six league derbies and is offered at 19/20 (1.95).
Opposing an early strike could also pay dividends and with both sides keen to avoid defeat, it could well be a cagey opening with no goal before 29 minutes available at 5/6 (1.83).
Prices correct at time of writing. Please gamble responsibly.