Zinedine Zidane's side lost 3-2 at Sevilla in a rearranged fixture on Wednesday night as the French coach left out a string of first-team regulars at the Sanchez Pizjuan.
Along with Cristiano Ronaldo and Dani Carvajal (injured) and Gareth Bale (suspended), Zidane rested Keylor Navas, Raphael Varane, Marcelo, Luka Modric, Toni Kroos and Isco for the midweek match, which leaves Real in third place, 18 points behind champions Barcelona with two games left.
Madrid's main focus, of course, will be the Champions League final against Liverpool later this month. But here, Goal takes a look at everything you need to know ahead Saturday's game at the Bernabeu...
Real Madrid injuries
Ronaldo is set to miss out again after suffering a sprained ankle against Barcelona last Sunday, which saw the Portuguese withdrawn at half-time in the Clasico. Meanwhile, Carvajal is not quite ready to return from injury. Isco is fit again and should be back after he was rested on Wednesday.
Real Madrid suspensions
Gareth Bale was banned for the trip to Sevilla on Wednesday, but the Welsh winger returns for this one.
Real Madrid potential starting line-up
With Bale back from suspension, the Welshman should start in attack for Real Madrid on Saturday – possibly alongside Borja Mayoral with Karim Benzema on the bench.
Cristiano Ronaldo is still out, with the priority for the Portuguese to focus on a return to fitness ahead of the Champions League final later this month.
Isco should feature for the first time after injury, while Navas, Modric, Kroos, Marcelo and Varane are all expected to return to the starting line-up following their rest for the Sevilla game on Wednesday.
Celta Vigo team news
This has been something of an inconsistent season for Celta Vigo, with the Galicians safe from relegation but not challenging for a place in European competition.
Juan Carlos Unzue's side are down in 12th position with 46 points, but they have been able to raise their game for the big teams, drawing home and away with Barcelona and also against Real Madrid at Balaidos in January.
Spain striker Iago Aspas could return from injury at the Bernabeu, but winger Emre Mor and defensive midfielder Nemanja Radoja are both doubtful.
TV channel & kick-off time
Celta Vigo versus Real Madrid kicks off at 8:45pm local time on Wednesday and will be shown live in the United Kingdom (UK) on Sky Sports Mix fom 7:40pm BST.
In the United States (US), the match is live on beIN Sports and kicks off at 2:45pm ET.
Best Opta match facts
Celta are winless in their last seven league games against Real Madrid, drawing one, losing six and conceding 3.5 goals per game (25 in total).
The Galicians have not won any of their last five La Liga games (three draws and two defeats), their longest run without a win under Unzue.
Real Madrid are unbeaten in their last eight La Liga home games (won six, drawn two), scoring 3.6 goals on average, after losing their previous two.
Toni Kroos has scored three goals against Celta in La Liga, more than he has against any other side in the competition.
Gareth Bale has been directly involved in three of Real Madrid’s last six goals at the Santiago Bernabeu in La Liga (two goals, one assist).