The Portugal star has served his five-match domestic suspension and is set to make his first league appearance of the season at the Santiago Bernabeu.
|Game||Real Madrid vs Real Betis|
|Date||Wednesday, September 20|
|Time||21:00 BST / 16:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports Mix and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports Mix||Sky Go|
In the US, the match will be available to watch live on television on beIN Sports and by stream via beIN Sports Connect.
|US TV channel||Online stream|
|beIN Sports||beIN Sports Connect|
SQUADS & TEAM NEWS
|Position||Real Madrid players|
|Goalkeepers||Navas, Casilla, Zidane|
|Defenders||Carvajal, Ramos, Varane, Nacho, Marcelo, Achraf|
|Midfielders||Kroos, Modric, Casemiro, Llorente, Asensio, Isco, Ceballos|
|Forwards||Ronaldo, Bale, Vazquez, Mayoral|
Real Madrid will be boosted by the returns of Ronaldo and Marcelo from suspension as well as Toni Kroos, who is expected to be fit after missing the match against Real Sociedad.
Theo Hernandez will miss a couple of weeks with a dislocated shoulder, though, and Karim Benzema, Mateo Kovacic and Jesus Vallejo are also out.
Potential starting XI: Navas; Carvajal, Varane, Ramos, Marcelo; Ceballos, Casemiro, Kroos; Isco; Bale, Ronaldo.
|Position||Real Betis players|
|Defenders||Navarro, Feddal, Amat, Durmisi, Barragan, Mandi, Firpo|
|Midfielders||Garcia, Ruiz, Camarasa, Boudebouz, Nahuel, Joaquin, Guardado|
|Forwards||Leon, Sanabria, Campbell, Tello, Guerrero|
Betis are missing Alin Tosca and Juanjo Narvaez, and coach Quique Setien has hinted he may have to rest 36-year-old Joaquin despite his two-goal outing at the weekend.
Joel Campbell is back in training but unlikely to feature and this match might come too soon for Ryad Boudebouz to make his first start despite his brief cameo on Saturday.
Potential starting XI: Adan; Barragan, Mandi, Feddal, Durmisi; Camarasa, Garcia, Guardado; Sanabria, Leon, Tello.
BETTING & MATCH ODDS
Madrid are 1/9 favourites to win, according to dabblebet , with Betis priced at 22/1 and the draw available at 9/1.
After a couple of disappointing draws, Real Madrid welcome Cristiano Ronaldo back into the fold feeling more upbeat on the back of their 3-1 win over Real Sociedad.
Sociedad had won three games in a row to start the season but Madrid got an opening goal from youngster Borja Mayoral, making his first start of the season, and a sublime third from Gareth Bale.
That Mayoral looked ready to contribute and Bale gave himself a shot in the arm is a big boost in the absence of Karim Benzema.
Now, Madrid get Ronaldo back and suddenly look spoilt for choice rather than stretched again.
They can choose between Bale, Ronaldo, Marco Asensio and Lucas Vazquez as well as Mayoral up front and have Isco, Toni Kroos, Luka Modric and Dani Ceballos among their options around anchorman Casemiro in midfield.
Ceballos is one of few players yet to be worked into the starting lineup and could get his chance against his former club.