The Eindhoven outfit have made a stunning start domestically with seven Eredivisie wins so far this season, scoring 26 goals and conceding just three.
Inter trio Mauro Icardi, Marcelo Brozovic and Ivan Perisic all started on the bench for the weekend win over Cagliari, but all three should could back into the starting eleven on Wednesday night.
PSV coach Mark van Bommel fielded his strongest eleven at the weekend and is likely to do so once more against Inter.
PSV are unbeaten in any competitive game in their own stadium since July 2017 and while the calibre of opponent has not been exceptionally high during that run, Van Bommel's men look dangerous when stepping out at the Philips Stadium.
Those are the only two defeats in their last eight home matches in the competition and with the side flying and scoring goals, they should be able to cause Inter some problems in the Italians' first Champions League away match for seven years.
Tips and predictions
The hosts are priced at evens (2.00) in the Draw No Bet market and that is worthy of consideration, given the Dutch side's form and relatively strong home form in Europe.