Brian Wepo and Vincent Ngesa, who were injured during the defeat to Kakamega Homeboyz on Thursday, have both been ruled out with injuries
Wepo collided with Allan Wanga and suffered a habitual dislocation of the patella of the right knee.
Ngesa, after colliding with Maxwell Ravel, is said to have suffered an avulsion fracture of his right knee.
“Those are the two players who will not be part of the team that will take on Tusker at Ruaraka this weekend," Nzoia Sugar’s team doctor Amir Magwara told Goal.
"Wepo was injured in the 38th minute of play against Kakamega Homeboyz and his injury will keep him out for a considerable period."
Nzoia Sugar will be looking for a first win since April 27, when they defeated Chemelil Sugar 2-1 at home.
Kenyatta Stadium in Machakos was originally scheduled as the venue, but the KPL brought it to Ruaraka, a ground that underwent renovation from late March.