The Golden Eaglets lead the Group A standings with six points following back-to-back victories against Tanzania and Angola.
The Nigerians only need a draw to see them through to the semi-finals of the competition and qualify for the U17 World Cup in Brazil.
However, the former Nigeria international, who played 60 times for the Super Eagles and scored eight goals, has charged the five-time world champions to look beyond a draw in the match.
“So far they have done very well. Already they have six points and have not lost any game, kudos to them,” Nwosu told Goal.
“Against Uganda, they must not be too comfortable, they have to go for a win and put in their best in the game.
“Winning should be their aim against Uganda because if they focus on a draw they might end up losing the game.
“They must know that they are playing for themselves first, before playing for Nigeria, so they must do everything to continue doing well.”
Nigeria missed several scoring chances in their last game against Angola and Nwosu wants them to pray for luck against Uganda as well as work on their individual skills.
“I will advise them to pray for luck to be able to score because it is a factor and they should work towards it by improving on their individual skills.”
The Golden Eaglets have won the U17 Africa Cup of Nations twice in 2001 and 2007.