Pep Guardiola's men are aiming to make history as they chase an unprecedented four trophies this term. The League Cup has already been won and the men from Manchester hope that Premier League, Champions League and FA Cup titles are to follow.
Chris Hughton charges will write themselves into Brighton folklore should they win the trophy for the first time in the club's history.
There is no question that Guardiola's side represent a huge hurdle for the Seagulls to overcome. Manchester City have progressed from 10 of their 13 FA Cup semi-final appearances. The odds compilers offer just 1/7 (1.14) that the men from Manchester win inside 90 minutes at Wembley.
Brighton have failed to win any of their previous four matches at this venue and the 14/1 (15.0) quote from bet365 for the Seagulls to win inside normal time is reflective of the task facing Hughton's men. The same firm go 7/1 (8.0) that the match remains deadlocked after 90 minutes.
Brighton have needed extra-time and penalties on the road to Wembley. The Seagulls saw off West Brom after extra-time in round five. That was followed by a nerve-shredding penalty shoot-out win against Millwall in the quarter-finals.
Sergio Aguero missed the midweek win over Cardiff and could sit out again ahead of the first-leg of City's Champions League tie with Tottenham Hotspur on Tuesday.
Indeed, Guardiola may opt to rest a few first-team regulars ahead of that crucial clash in north London. There are issues at left-back though as Oleksandr Zinchenko looks unlikely to feature after picking up an injury on Wednesday night while Fabian Delph has also been ruled out.
The Seagulls are sweating over the availability of Solly March. The talented winger was substituted during the first-half of Wednesday's match against Chelsea after sustaining an injury. Leon Balogun and Pascal Gross, who both missed the trip to Stamford Bridge, will be assessed.
Goals galore at Wembley
Guardiola's men are the top scoring side in English football this season. As such, the 8/11 (1.73) quote from bet365 for City to score three or more goals here may prove popular.
The same firm go 13/8 (2.63) that there are goals at both ends. That selection would have landed in four of Brighton's five FA Cup ties thus far this term but this is undoubtedly thier toughest assignment of that run.
No side have scored more FA Cup goals than Manchester City's tally of 19 so far this season. Indeed, should City score on Saturday, it will be the first time they have notched 20 in this competition since 1981. In that year, of course, they reached the final.
Value, then, may lie in backing Manchester City to win a tie in which at least four goals are scored. The 5/4 (2.25) selection would have paid dividends in each of the four ties that Guardiola's men have won on their way to Wembley this season.
Odds correct at time of writing. Please gamble responsibly.