The news that Kevin De Bruyne is set to miss a significant amount of the season is a blow to Manchester City backers in various markets.
The defending Premier League champions had few problems in getting past Arsenal last time out though, and the bookmakers expect another three points against Huddersfield on Sunday.
SportPesa make City their 2/25 (1.08) favourites to continue their winning start. Huddersfield are made 27/1 (28.0) outsiders - making them the biggest underdogs in England's top four divisions this weekend by some distance - while the draw is 11/1 (12.0).
De Bruyne joins Eliaquim Mangala on the side-lines for the hosts while David Wagner will be without the services of Elias Kachunga and Daniel Williams.
Many punters will want to side with Manchester City in some way, the question is likely to be how to do so at an attractive price? Backing City to win to nil (5/9), or -2 (20/27) are still probably too short for most as a single selection. In fact, the best option could be to go against the expectation that Guardiola's men are set to run riot on home soil.
While the gulf between the teams is obvious, Huddersfield claimed a 0-0 draw from this exact fixture last season and only lost 2-1 in the reverse meeting.
In fact, while Wagner's side only scored once in their away matches against last season's top six, they conceded 13 times with five of those goals coming in one game against Arsenal.
A Manchester City win is the logical choice but the current odds make it tough to find a selection that appeals along those lines. Instead, punters should consider opposing a high-scoring game with under 3.5 goals available at 20/21 (1.95) with SportPesa.
This would have landed in both league meetings between the pair last term and while the hosts have the tools to dismantle teams in the final third, Huddersfield's tactics will be to try and frustrate their illustrious hosts by adopting a defensive approach.
While that won't always ensure their opposition don't find plenty of joy going forward, the fact that this bet would have won in five of the Terriers' trips to last season's top six gives an indication of what to expect from the outsiders.
With Guardiola's side still getting up to speed ahead of a long season, a relatively low-scoring match would be no surprise and at 20/21 (1.95) the under 3.5 goals line offers a much more attractive selection for bettors ahead of Sunday's clash.Under 3.5 goals at 20/21 (1.95) for a 2pt stake with SportPesa