Pep Guardiola's side secured their 24th league win out of a possible 28 when they beat Arsenal 3-0 on Thursday and they need just five more wins to clinch the title.
Antonio Conte's men, meanwhile, find themselves in a battle to secure a top-four finish after recent results saw them tumble down to fifth in the table.
City overcame the defending champions back in September when they played at Stamford Bridge, but it was a close game and Sunday should be a similarly tight match.
|Game||Manchester City vs Chelsea|
|Date||Sunday March 4|
|Time||16:00 GMT / 11:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN / NBC Universo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Position||Man City players|
|Goalkeepers||Bravo, Ederson, Grimshaw|
|Defenders||Walker, Danilo, Kompany, Stones, Laporte, Adarabioyo, Otamendi, Duhaney|
|Midfielders||Sterling, Gundogan, De Bruyne, Sane, B. Silva, D. Silva, Fernandinho, Zinchenko, Toure, Foden, Diaz, Dele-Bashiru|
|Forwards||Aguero, Nmecha, Jesus|
Fernandinho will miss out as he recovers from a muscle injury but Raheem Sterling is in contention to return.
Kyle Walker will be involved, but Fabian Delph is suspended and Benjamin Mendy is injured.
Potential Man City starting XI: Ederson; Walker, Otamendi, Kompany, Danilo; Gundogan, D. Silva, De Bruyne; Sane, Aguero, Sterling.
|Goalkeepers||Caballero, Courtois, Eduardo|
|Defenders||Rudiger, Alonso, Zappacosta, Azpilicueta, Cahill, Luiz, Emerson, Christensen, Ampadu, Sterling, Chalobah|
|Midfielders||Fabregas, Drinkwater, Kante, Barkley, Hazard, Pedro, Bakayoko, Moses, Willian, Scott, Hudson-Odoi|
Ross Barkley is available for selection again following injury but it remains to be seen if Conte will throw him in to such a big game.
David Luiz and Tiemoue Bakayoko are both out of action with injuries, while Alvaro Morata is a concern as his back issues persist.
Potential Chelsea starting XI: Courtois; Azpilicueta, Christensen, Rudiger; Alonso, Moses, Kante, Hazard, Fabregas, Willian; Giroud.
Betting & Match Odds
Man City are heavy favourites to win at 6/10 according to dabblebet, who price Chelsea at 5/1 to win at the Etihad Stadium. A draw is available at 16/5.
The difference in fortunes between Chelsea and Man City this season can be summed up by the fact that 22 points separate them coming into their second encounter of the campaign.
Conte, whose Blues side battled their way to Premier League glory last term, has looked on with envy as his counterpart Guardiola cruises towards the finish line this season and he admitted that City sometimes seem "unstoppable".
"We must have great admiration. Sometimes it is very difficult to find a weakness in this team," the Blues boss said, adding: "Manchester City has the possibility to spend a lot of money. When you link this situation - a good manager, much money to spend in the transfer market, the same ambition - this is the final result."
The Italian coach finds himself under increasing pressure at Chelsea, but he could serve his detractors a reminder of his quality by getting one over on Guardiola's seemingly invulnerable team.
A win would keep them within touching distance of the top four, but failure to pick up three points will be a blow to their hopes of ensuring Champions League football next season.
Notably, however, Conte's men have had a longer period of rest than their hosts, having not played since February 25, and they will be eager to take advantage.