City do not play until Sunday when they travel to Huddersfield Town, so Liverpool can reclaim their seven point lead at the top until then at least.
Jurgen Klopp's side were not at their fluent best against Brighton last time out, only beating the Seagulls 1-0 at the Amex Stadium thanks to a second-half penalty from Mohamed Salah.
|Game||Liverpool vs Crystal Palace|
|Date||Saturday, January 19|
|Time||3pm GMT / 10am ET|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live on NBCSN or livestreamed on NBC Sport Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
In the United Kingdom (UK), the game will not be televised or livestreamed due to the 3pm Saturday blackout law.
|UK TV channel||Online stream|
Squads & Team News
|Goalkeepers||Alisson, Mignolet, Grabara|
|Defenders||Clyne, Alexander-Arnold, Van Dijk, Lovren, Gomez, Robertson, Matip|
|Midfielders||Fabinho, Wijnaldum, Keita, Henderson, Lallana, Camacho, Jones, Shaqiri|
|Forwards||Mane, Salah, Firmino, Sturridge, Origi|
Jurgen Klopp's defensive headache received a fresh blow last week with the news that Trent Alexander-Arnold will be ruled out for up to four weeks with a knee injury.
The right-back joins Dejan Lovren (hamstring) and Joe Gomez (leg) in the treatment room.
That means James Milner returns to right-back at Anfield, while Joel Matip has recovered from a broken collarbone to partner Virgil van Dijk at centre-back, despite Fabinho's impressive performance against Brighton.
The ex-Monaco man returns to midfield, where he partners Jordan Henderson and Naby Keita, who makes his first start since December as Georginio Wijnaldum and Adam Lallana both miss out with minor knocks.
Confirmed Liverpool XI: Alisson; Milner, Matip, Van Dijk, Robertson; Henderson, Fabinho, Keita; Mane, Salah, Firmino.
Bench: Mignolet, Sturridge, Moreno, Lallana, Shaqiri, Origi, Camacho.
|Position||Crystal Palace players|
|Goalkeepers||Hennessey, Guaita, Speroni|
|Defenders||Sakho, Tomkins, Reidewald, Dann, van Aanholt, Souare, Wan-Bissaka, Ward, Kelly|
|Midfielders||Millvojevic, Kouyate, McArthur, Schlupp, Meyer, Kaikai, Townsend|
|Forwards||Zaha, Benteke, Ayew, Wickham|
Palace's two first-choice keepers, Vicente Guaita and Wayne Hennessey, both picked up injuries against Watford last weekend.
As neither are fit, Julian Speroni takes his place in goal in the only change to the Palace starting XI.
Christian Benteke, meanwhile, is on the bench could feature against his old club after returning from injury against the Hornets.
Confirmed Crystal Palace XI: Speroni, Wan-Bissaka, Sakho, Tomkins, Van Aanholt; Milivojevic, Kouyate, McArthur; Townsend, Zaha, Ayew.
Bench: Tupper, Kelly, Dann, Schlupp, Meyer, Wickham, Benteke.
Betting & Match Odds
Liverpool are unsurprisingly heavy favourites at 1/6 with bet 365. Meanwhile, a draw is rated at 13/2 while Palace are 12/1 to pull off an upset.
Liverpool will be looking to lay down a marker when they take on Palace nearly 24 hours ahead of City's clash with Huddersfield.
Speaking after the match, Klopp said: "It was a really mature performance from my side. This season that is a new skill and we have to keep that.
"The second half was much better. We learned from the first half. So I like the performance.
"It's not an opera of football but it’s still a really nice song."
The Liverpool boss insisted the Reds' cannot rest on their laurels though and wants his team to stay focussed despite their lead at the top.
"It means nothing," he added. "We take all the points we can. We have 57 now – that's the situation and that's cool."
Palace will hope to stall that lead, and Roy Hodgson's side could be a tough test for the league leaders.
The Croydon-based club are still in a precarious position, just four points above the drop zone, and need to bounce back after a 2-1 home defeat to Watford in their last game.
Hodgson's men have been compact and hard to break down this term, having only conceded 28 times in 22 Premier League games, and Wilfred Zaha and Andros Townsend provide considerable pace in attack.