The England international has been used as a substitute by Jurgen Klopp nine times since his deadline-day switch from Arsenal, with his only other run out from the off coming in the League Cup defeat at Leicester.
Coutinho (adductor) and Lovren (thigh) have not shaken off their injuries in time to feature on Wednesday night, with the Reds boss introducing four changes to the starting line-up from the weekend’s 3-0 victory over Huddersfield.
Loris Karius replaces Simon Mignolet in goal, with Trent Alexander-Arnold at right-back and Joe Gomez on the bench.
Jordan Henderson is rested in the centre of the pitch with Emre Can starting as the deepest midfielder and Daniel Sturridge is among those in reserve with Oxlade-Chamberlain joining the attack.
Maribor, meanwhile, are looking to keep their Champions League hopes alive after suffering a 7-0 reverse last time round in Slovenia to the Reds.
Captain Marcos Tavares drops to the bench, with Jasmin Mesanovic entering a defence-minded starting XI at Anfield.
Liverpool starting XI: Karius, Alexander-Arnold, Matip, Klavan, Moreno, Can, Milner, Wijnaldum, Chamberlain, Salah, Firmino.
Liverpool subs: Mignolet, Gomez, Robertson, Henderson, Grujic, Solanke, Sturridge.
Maribor: Handanovic; Milec, Rajcevic, Suler, Viler, Billong; Kabha, Pihler, Hotic, Bohar; Mesanovic.
Maribor subs: Obradovic, Vrhovec, Ahmedi, Vrsic, Bajde, Tavares, Palcic.