And while the north London club pray he will recover from a hamstring injury in time for the huge fixture , Vertonghen underlined Kane's importance to the side.
Indeed, the Belgium defender rates Kane on the same level even as Cristiano Ronaldo, whom he will be facing at Wembley.
"They are both unbelievable players," Vertonghen said to reporters on Tuesday. "Ronaldo has his qualities and Harry has his.
"We have to show respect to Ronaldo for what he has won, his level and how he is still doing it.
"Harry for me is one of the best No 9s in Europe, maybe the best. He shows that every week and I wouldn't swap Harry for any player at the moment."
With three games played so far in the Champions League group stage, Madrid and Spurs have streaked ahead of Borussia Dortmund and APOEL in the race for the last 16.
The two sides are currently tied on seven points with identical records, although Dortmund will hope to close the gap with victory at Signal Iduna Park as at least one of the front-runners is guaranteed to drop points.