No move was made in January, but gossip regarding a potential big-money switch refuses to go away.
A departure by Perisic from the San Siro to the Premier League is considered the most likely option, with there plenty of English interest in the 28-year-old.
Simic believes another high-profile transfer could be in the offing, saying Perisic could make the grade at Old Trafford.
He told Vecernji : “At Inter our guys Marcelo Brozovic and Ivan Perisic play a key role.
“I expected Perisic in the last transfer window to go to one of the big European clubs.
“He definitely has enough class for the greatest clubs – I see him at Manchester United.”
Perisic has scored seven times for Inter in all competitions this season, but was sent off as tempers boiled over during Inter’s recent 1-0 defeat to rivals Juventus.