The 31-year-old made his Afcon debut in 2008, going ahead to play in 2010, 2012, 2013, 2015 and now 2017.
“I feel blessed, because it’s not easy playing six Afcon tournaments," Gyan said, as reported by Citi FM Online.
"I still feel strong despite recent injuries which have slowed me down a bit.
“It is frustrating [that we have not won the trophy since 1982], but we will try and make sure we carry the cup home.
"It is, however, too early to be talking about winning the trophy [at this stage of the tournament]. We just have to be more composed to do what we do best, that’s winning games and we will see what happens.
“Personally I do worry a lot, even now that I am leading the team. It’s quite frustrating having this group of quality players and not taking anything home."
Gyan could be in for another landmark when he lines up against Mali in their second group game on Saturday.
The frontman currently ties teammate Andre Ayew and ex-national star Osei Kofi as Ghana's all-time top scorer at the Afcon, and a goal on Saturday will leave him clear.
The Black Stars have not won the Afcon since 1982.