Asamoah deputized for Alex Sandro at left back with the South American returning late from international duty and featured throughout as Ciro Immobile netted a second-half brace for Lazio to cancel out Douglas Costa's opener.
This was the first time, since the opening day of the 2015/16 season, that Juventus lost a game at the Allianz Stadium.
The Ghanaian utility man was making his fourth appearance of the campaign for Massimiliano Allegri’s men and despite being one of the few standout performers for Juve in the defeat, Asamoah was on the receiving end of a social media attack from a few Juventus fans.
'How many times do you pass back the ball during a match? One or two hundred?' , wrote Andrea Barone (@andybarone68)
'Go to Turkey u piece of s**t', said - @fin0allafine
Hendra Nucleo (@nuovonucleo) also wrote , 'Can you leave juventus @Asabob20 ? many thanks for your service.'
He was not alone in the attack though as Sami Khedira and Andrea Barzagli were also told join the former Black Stars men through the exit door in January.
Asamoah is being linked with a move away from the Turin side with Galatasaray said to be the possible destination.
Reports have also suggested that the club is preparing for life without him and they've already earmarked Atalanta's Leonardo Spinazzola as well as Paris Saint-Germain's Thomas Meunier as his possible replacements.
Juve are in action again on Wednesday as they will welcome Sporting and Asamoah is expected to return to the bench.