bet365 make the Blues 4/1 (5.0) favourites to lift the trophy for the first time since 2013 - the last time they played in the competition – and should have few problems seeing off Malmo in the first knockout round.
With their prospects of a top four finish in the Premier League slipping away thanks to three losses in four games, winning the Europa League could represent their last chance to be in next season’s Champions League.
Arsenal also do not occupy a top four place, having lost three of their last seven league games, and are 6/1 (7.0) with bet365 to win this competition for the first time ever.
The Gunners, led by three-time Europa League winner Unai Emery, reached the semi-finals last season but will hope to go further this time around and make a return to Europe's top table.
Napoli can be found at 6/1 (7.0) too, ahead of their two-legged affair with FC Zurich. The Italians are comfortably second in Serie A and it remains to be seen whether Carlo Ancelotti will aim for a deep European run.
Available at 10/1 (11.0) are Inter, who play Rapid Wien, but the Milan club are embroiled in a battle for a top four spot in their domestic league and may prioritise that over trying to claim a seventh European crown, at least for now.
Sevilla are the most successful club of all time in this competition, winning it five times including three times in a row between 2014 and 2016.
They are priced at 12/1 (13.0) with bet365, whilst their Last 32 opponents Lazio are available at 25/1 (26.0). Valencia can be backed at 18/1 (19.0) with Eintracht Frankfurt 20/1 (21.0) and Red Bull Salzburg 22/1 (23.0).