Ousmane Dembele has been ruled out for at least two weeks as his Barcelona career suffers another injury setback.
Subsequent tests have revealed a tear to the left ankle which will see him miss the next four matches.
He joins an injury list which already includes Rafinha and Samuel Umtiti, both of whom have knee injuries.
Since arriving from Borussia Dortmund, the 21-year-old's career at Camp Nou has been dominated by fitness issues.
A hamstring tear saw Demebele miss much of his first season at Barca, and he suffered a similar injury 12 months ago which again derailed his spell at the club.
But the 2018-19 campaign had been largely injury free for the Frenchman, helping him score 13 goals and contribute five assists in 27 appearances.
Ernesto Valverde's side are still fighting firmly on three fronts this season.
Sevilla are their opponents in the Copa de Rey as they pursue an unlikely quadruple, having already won the Spanish Super Cup at the start of the season