The Kumasi giants recorded their fourth defeat of the campaign against Great Olympics when they lost 2-0 on Saturday, stretching their winless streak to seven games.
And Manso, who was appointed last month to replace Croatian Zdravko Lugarusic, says none of his remedies is working for the club.
"Nothing seems to be working for us, sometimes you feel like it's going to be this weekend to turn the corner but then it's getting worse so for me yes, I'm having a difficult time to turn things around," Manso said.
"I met the situation but it's been very difficult for us to come out from this mess, I must be honest with that. We have tried to pinpoint the problem but to no avail."
"Anytime we try to solve the problems that we suspect might be the cause of our recent slump, we end up facing another and against Great Olympics it happened again. We had a terrible afternoon, so I think it's a big problem for all us," he added.
Kotoko sit fifth on the log with 20 points, nine points behind leaders Wafa who have a game at hand against Hearts of Oak on Monday.