Harry Kane made his return from six weeks out injured by scoring in the north Londoners' 2-1 defeat at Burnley on Saturday and the England striker will be aiming to help the side bounce back from that disappointment.
Chelsea will be hoping to recover from the blow of losing the Carabao Cup final on Sunday, and their top scorer Eden Hazard netted the last time his side faced Spurs in January in the semi-final of that tournament.
The shortest-priced player to score at Stamford Bridge is Gonzalo Higuain, with the Argentine forward priced at 5/4 (2.25) with William Hill to score at anytime. However, he has only scored in one of his six appearances since moving to west London in January.
Next in the betting comes Kane, who has scored in seven of his last eight matches for Spurs, at 11/8 (2.37) while Eden Hazard can be backed at 7/5 (2.40) to add to his tally of 12 league goals this term.
Chelsea played 120 gruelling minutes on Sunday before losing on penalties to Manchester City, and manager Maurizio Sarri could make some changes to his side.
Ruben Loftus-Cheek could come into the starting eleven and is offered at 13/5 (3.60) to score his seventh goal of the season in all competitions.
N'Golo Kante played the entire game against City, yet will surely start once again and offers an interesting option at 7/1 (8.00) to score. Harry Winks is the only Spurs midfielder to have scored a league goal in 2019 and is 10/1 (11.00) to do so once more.
Tips and predictions
Having scored against Spurs last month, Kante looks a tempting bet to find the back of the net. The France International looked dangerous in Sunday's final with some bursting runs from deep into the box and is currently enjoying his best ever scoring season in the Premier League.