Maurizio Sarri's side have taken maximum points from their opening four fixtures of the campaign and will be confident of extending their winning run against the Bluebirds.
Neil Warnock's men are still searching for their first win of the season, but Cardiff did score their first Premier League goals of the campaign in a 3-2 defeat at the hands of Arsenal before the international break.
SportPesa make the Blues their 1/6 (1.17) favourites to chalk up a fifth consecutive Premier League victory against the newly-promoted side on Saturday afternoon.
The enormity of the challenge facing Cardiff is reflected by SportPesa's 18/1 (19.0) quote for the visitors to claim a famous victory, while the odds compilers offer 13/2 (7.50) that Warnock's charges claim a share of the spoils.
Blues top scorer Pedro is pushing for a place in the starting line-up after opening the scoring as a second half substitute in Chelsea's 2-0 win against AFC Bournemouth last time out, with Willian most likely to drop the bench.
Cardiff could bring Aron Gunnarsson and Josh Murphy back from injury, but Nathaniel Mendez-Laing faces a prolonged spell on the sidelines and may not return before Christmas.
Chelsea to get amongst the goals?
The Blues have bagged 10 goals in four Premier League matches so far this season - only Manchester City have scored more - and they will fancy their chances of adding to that tally this weekend.
Cardiff conceded three times on home soil against Arsenal last time out and SportPesa go 20/23 (1.85) that Sarri's side score more than two goals against the Bluebirds in west London.
Cardiff have been competitive this season; Warnock's men have kept two clean sheets and have been beaten by a single goal on one occasion in four matches on their return to the top tier.
The trip to Stamford Bridge, though, looks likely to be a daunting one, for the Blues are in fine form and SportPesa's 6/5 (2.20) quote for Chelsea to win both halves could represent excellent value for punters ahead of Saturday's match.