The Blaugrana started their quest towards a sixth European crown with a 4-0 home win over PSV Eindhoven.
Things have not been going well for them in the Primera Division though as they are winless in their last two games and victory in London at odds of (2.05) with BetKing, would definitely give them a morale boost.
The Lilywhites started their Group B campaign on a losing note at Inter Milan, despite taking the lead.
Their 2-0 win at Huddersfield Town at weekend has left them four points from the summit of the Premier League log and the same betting firm tips them at (3.45) to get the better of their opponents from Catalonia.
Should the game end in a stalemate, odds of (3.70) are on offer.
Ernesto Valverde’s charges might have lost just one of their last 11 Champions League games against English clubs but they have won just once in their last seven away trips in Europe.
On the other side, Mauricio Pochettino’s men won all their group games at Wembley last season, scoring three goals in each of them.