The Gunners dropped just two points as they eased through the group stages, scoring 12 goals and conceding just two.
Having run out 6-0 and 4-2 winners against this opposition when they met in last season's group stages, they are 4/9 (1.44) favourites with William Hill to take command of this tie with an important away victory.
Alyaksey Baha's men won just one of their three group stage games in front of their own fans, but are on offer at 6/1 (7.00) to pull off a memorable home win here.
None of the hosts' six matches in this season's competition have resulted in draws, but there are odds of 17/5 (4.40) available on them keeping the scoreline all square in this one.
Bojan Dubajic, Nemanja Milic and Dmitri Bessmertny could be in line for a competitive debut after joining in January, while Aleksandr Hleb will be hoping to face his former club.
Pierre-Emerick Aubameyang and Mesut Ozil could return after missing Saturday's victory over Huddersfield through illness, although Sokratis, Hector Bellerin, Rob Holding, Granit Xhaka, and Danny Welbeck are all out and Aaron Ramsey is doubtful.
With the race for fourth place looking extremely competitive after Manchester United's recent renaissance, Unai Emery may fancy his chances of achieving Champions League qualification via this competition instead.
No manager has lifted this trophy more than the former Sevilla coach, and his side's group stage performance suggests he could well be in for more success this season.
In contrast, BATE have never reached beyond this stage of the competition, and are not helped by the lack of domestic football between December and April.
With the hosts bound to be rusty, odds of 11/10 (2.10) seem generous on Arsenal winning by at last two goals for the third meeting in a row between this pair.