The Gunners have won two of their last three home games against this opposition in the league, although went down 3-1 here in January's FA Cup tie.
With 12 wins and no defeats to their name in the last 14 league games in front of their own fans, they are bet365's 6/5 (2.20) favourites to steal a march in the hunt for Champions League qualification by coming out on top here.
However, Ole Gunnar Solskjaer's men set a club record of nine consecutive away wins with their thrilling 3-1 victory over PSG on Wednesday, and can be backed at 21/10 (3.10) to make it 10 in a row with another eye-catching result.
This pair shared a 2-2 draw in the reverse encounter at Old Trafford, and are priced at 5/2 (3.50) to cancel each other out once again.
Lucas Torreira is suspended after getting sent off in last weekend's North London derby, while Hector Bellerin, Rob Holding and Danny Welbeck are all injured.
Eric Bailly is unlikely to feature after going off injured in Paris, joining Alexis Sanchez, Juan Mata, Nemanja Matic, Ander Herrera, Jesse Lingard, Matteo Darmian and Antonio Valencia on the sidelines. However, Phil Jones and Anthony Martial could be in line for returns from illness and injury, respectively.
While their midfield options were limited at the Parc des Princes due to Paul Pogba's suspension and a long injury list, the Red Devils were able to count on the attacking threat offered by Romelu Lukaku and Marcus Rashford.
Having extended their record of scoring in every away match this season to 21 games in a row, the visitors will back themselves to find the target against a defence that has kept just two clean sheets in 13 league games.
However, Unai Emery's men are sure to pose their own threat considering they are the third top scorers in the league, and are averaging three goals a game over the last six league fixtures on home turf.
With a high-scoring match looking likely, odds of 10/11 (1.91) are well worth backing on both teams scoring in a match featuring over 2.5 goals for the fifth meeting in a row between Arsenal and Manchester United.
Odds correct at time of publish. Please gamble responsibly.