Eleventh on the league table, Paul Heckingbottom's outfit are poised to pick their 15th win of the season, one which could potentially catapult them to the eighth position.
Yiadom, a London-born with 28 appearances for Barnsley this season, is looking forward to the encounter at the Loftus Road Stadium for obvious reasons.
“It’s down onto my own area, I’m from London, so it’s alright for me," Yiadom told his club's official website.
"All the boys are excited to go to QPR, so we want to go there and put on a good performance.
"A lot of my family will be coming, so I definitely want to make sure we put a performance in and get the win.
“I think we will go into every game thinking we can win, not too long term at the minute.
"Everyone is saying we are definitely going to stay up but we need to keep going and in the next game we want to win.
"We don’t want to just see the season off because we’re safe, we want to beat these big teams like QPR etc."
Yiadom joined Barnsley on a free transfer from League Two outfit Barnet in May last year.
He has also played for lower division sides Braintree Town FC and Hayes and Yeading FC.