Both teams are top of the English Premier League standings on 19 points - with only a goal difference advantage putting the Citizens clear in first position.
The Reds have had a stunning start to the season - winning all but one of their league matches and defeating Paris Saint Germain in the Champions League.
But Jurgen Klopp's men showed signs of weakness and fatigue during a 1-0 loss to Napoli in Europe's premier club competition mid-week.
Attacking superstar Mohamed Salah has only three goals to this name so far this season, but he has been getting into dangerous areas every match and is primed to explode this match.
In his three games against Manchester City in 2018, the Egyptian has contributed to five goals and City coach Pep Guardiola will be worried about his potential impact.
Liverpool have made Anfield a fortress over the past couple of seasons - having not lost any of the last 24 matches in front of their beloved Kop.
On the flip side, Manchester City have been extraordinarily strong away from home over the same period - with their only loss in 25 matches on their travels coming in this exact fixture last season.
Despite the absence of star playmaker Kevin De Bruyne, the City machine has been rolling nice - having only dropped two points during their league campaign in a draw against Wolves.
Their star striker Sergio Aguero has five goals in seven league matches this season, but has failed to score in all nine games he has played at Anfield with City and previous club Atletico Madrid.
Guardiola has been an incredibly successful at every club he has managed, but he has always had issues against Klopp-coached teams.
Expect an absolutely cracking match on Monday (AEST) as both teams go toe-to-toe for 90 minutes.