Polokwane, who have record a single win in their last five league games, are set to host fellow strugglers SuperSport at the Old Peter Mokaba Stadium. Kick-off is at 19h30.
Rise and Shine are placed 13th on the PSL standings having lost 1-0 away to Maritzburg United in their previous encounter a fortnight ago.
They are only three points above the relegation zone and they will look to league’s top goalscorer Rodney Ramagalela to produce the good against SuperSport.
Matsatsantsa, who won their last competitive game 2-1 against Angolan side Petro de Luanda in the Caf Confederation Cup, are winless in their last four domestic league games.
The Tshwane giants are placed 14th on the log with 27 points from 24 matches - only three points above the relegation play-off spot.
Thabo Mnyamane, who netted twice against Petro de Luanda, could be key to Matsatsantsa’s victory over Rise and Shine.
Polokwane City duo of Sibusiso Sikhosana and Simphiwe Hlongwane will miss the game due to suspension, while SuperSport captain Dean Furman is also suspended.
Polokwane and SuperSport have met nine times in the league previously, with the latter winning four games compared to Rise and Shine’s one, while three games ended in draws.
The two teams drew 1-1 in the first league game in Tshwane earlier this year.
Meanwhile, Arrows will travel to the Cape Town Stadium where they are scheduled to take on top eight hopefuls Cape Town City. Kick-off is at 19h30.
Abafana Bes’thende, who have lost three of their last five league games, were beaten 2-1 by Orlando Pirates at home in their previous match two weeks ago.
The defeat left Arrows in 12th position on the log with 27 points from 24 matches. They are three points above the relegation zone.
Jabulani Shongwe, who scored against Pirates last month, will be looking to find the back of the net yet again and help his side return to winning ways against City.
The Citizens are coming off a 2-1 defeat to Mamelodi Sundowns in the Nedbank Cup match having also lost four of their last five league games.
They are placed sixth on the table having accumulated 34 points from 24 games. They are three points behind fourth-placed Free State Stars.
City’s dangerman is Bradley Ralani, who is in good form at the moment having grabbed an assist and a goal in his last two games. Both City and Arrows have no suspension concerns.
The two teams have met three times in the league, and recorded one win each, while the other match ended in a draw in the first round clash in November 2017.
Lastly, relegation-threatened Platinum Stars will welcome top eight hopefuls Baroka FC at the Royal Bafokeng Stadium. Kick-off is also at 19h30.
Dikwena suffered their third consecutive defeat when they lost 1-0 away to Bloemfontein Celtic two weeks ago.
Bonginkosi Ntuli remains Dikwena’s main striker and the North West-based side will be hoping that Sundowns loanee regains his scoring form against Baroka.
MacDonald Makhubedu's men lost 1-0 to Kaizer Chiefs in the Nedbank Cup game over the weekend, but they're unbeaten in their last four league games having played to a 1-1 draw with defending league champions Bidvest Wits away two weeks ago.
The Limpopo-based side is placed seventh on the log with 32 points from 24 games. They are two points behind sixth-placed City.
Mpho Kgaswane, who missed Baroka's clash with Chiefs, is back from suspension and the attacker could be key to Bakgaga's victory in Rustenburg.
Stars head coach Roger de Sa will not be on the bench as he is expected to serve his suspension. Baroka do not have any suspension to worry about.
Stars and Baroka have met three times in the league. Bakgaga are undefeated against Dikwena having recorded one win and two draws against their opponents. The two teams drew 2-2 in Polokwane last November.