Ryan Giggs' men will be confirmed as group winners should they defeat the Danes, but defeat would see Age Hareide's side snatch top spot.
The stage is set, then, for a big night in the Welsh capital and the home side are chalked up as a 17/10 (2.70) chance to claim the victory that they desperately crave.
Denmark, though, defeated Wales in this competition back in September and Hareide's side are available at 7/4 (2.75) to double their delight against Giggs' outfit.
A draw would keep Wales at the summit for now and SportPesa go 2/1 (3.0) that this match ends all square and that the final outcome of the group goes down to the wire.
Gareth Bale sat out of Wales' win in Dublin last month through injury and the Real Madrid man will have an ankle injury assessed ahead of this match, but Wales are confident that Bale will be fit to face the Danes.
Age Hareide will be happy to have Christian Eriksen in his ranks after the midfielder missed out on last month's matches but a hamstring injury will prevent Danish captain, Simon Kjaer, from lining up in Cardiff.
Denmark have kept a clean sheet in each of their last three fixtures and SportPesa go 33/20 (2.65) that Giggs' men draw a blank in the Welsh capital.
Furthermore, there have more than two goals in just one of Denmark's last 12 fixtures and the odds compilers offer 1/2 (1.50) that there are fewer than three goals on this occasion.
Wales, though, have scored in all but one of their last 11 home matches and, roared on by a passionate home support, Giggs' side will feel that they can get amongst the goals here.
With Denmark in need of a positive result, Hareide's side will surely be willing to push forward and the 11/10 (2.10) quote from SportPesa for both teams to score could represent real value for punters ahead of Friday's fixture.