Saturday evening's game in Sochi has the potential to be one of the most keenly contested ties in the last 16 of the World Cup.
Uruguay qualified for the knockout stages top of Group A, having won all three group games for the first time ever.
For that reason, the draw is offered at lower odds than one would usually expect to see for a high-profile international clash at just 19/10 (2.90).
The 23-year-old returned to training on Wednesday and is pushing for a return to the starting eleven.
Uruguay are the only side yet to concede a goal in the tournament, although their group was arguably one of the weakest in the competition.
Nevertheless, there is plenty of merit in keeping three clean sheets in this most open of World Cups and Oscar Tabarez's side will be looking for another shutout against Portugal.
The European champions are not renowned for their attacking flair, although they have managed to find the back of the net in all three games at the tournament so far.
Despite both sides boasting world-class attacking players, they are both naturally defensive in their outlook and we should expect Saturday's game to be one of the tightest in this round of matches.
Tips and predictions
These sides are going to be hard to split and backing the game to go to penalties at 9/2 (5.50) looks like an excellent option for a value bet.
Also worthy of consideration is backing at draw at both half time and full time at 27/10 (3.70), which seems like an intelligent way of backing a stalemate.