Despite some thrilling performances away from their temporary home, Mauricio Pochettino's side currently sit third in the Premier League table after a run of inidifferent performances at the national stadium.
Jurgen Klopp's side, meanwhile, secured a much-needed morale boost with a 7-0 win over Maribor in midweek, having won just one of their previous eight games in all competitions.
But which players available for selection from both sides would make a combined XI judged on their form so far this season? Goal does its best to pick such a team...
HUGO LLORIS (Tottenham): Given the inconsistency in Klopp's selection of his goalkeepers, Lloris would likely have walked into this team, but his form over the past week has further cemented him as one of the world's best. Unbelievable saves against both Bournemouth and Real Madrid ensure he picks up the No.1 jersey.
JOE GOMEZ (Liverpool): Having missed almost the entirety of the last two seasons, the England Under-21 captain is certainly making up for lost time at Anfield this term. Though he has had to vie for his place with Trent Alexander-Arnold, the former Charlton defender put in arguably his best performance of his Reds career in last week's draw with Manchester United.
DAVINSON SANCHEZ (Tottenham): While many believed the 21-year-old was being signed as a back-up for Pochettino's established centre-back pairing, the summer arrival from Ajax has slotted in nicely to the Spurs backline, having showed a maturity beyond his years.
JAN VERTONGHEN (Tottenham): Now Belgium's record appearance-maker at international level, Vertonghen has yet again been a model of consistency both at centre-back and on the rare occasion he has been pressed into action on the left-hand side of a back four.
BEN DAVIES (Tottenham): He may not grab the headlines, but Wales international Davies has proven a more than able deputy for Danny Rose thus far. The former Swansea full-back has improved his attacking game immeasurably, highlighted by his two goals already this campaign, and could yet keep his place in the starting XI despite Rose's return to fitness.
MOUSSA SISSOKO (Tottenham): Having seemed on his way out for much of the summer, Sissoko has finally looked back his best on a consistent basis after a spate of injuries within the Spurs midfield. Put in perhaps his best performance against Real Madrid in midweek as he impressed at both ends of the pitch.
HARRY WINKS (Tottenham): Another to benefit from the fitness problems in Pochettino's squad, academy graduate Winks has taken the next step in his development with a series of eye-catching showings. His form earned him a first senior England cap and now looks set to challenge for a place in Gareth Southgate's World Cup squad.
PHILIPPE COUTINHO (Liverpool): Having sat out the opening weeks of the season amid speculation regarding his future, Coutinho has needed little time to rediscover his best form. Stunning goals against Leicester City and Newcastle have suggested he will remain a key figure at Anfield this term, though has looked his best as part of a midfield trio rather than further forward.
CHRISTIAN ERIKSEN (Tottenham): One of the standout Premier League players of 2017, the Dane continues to produce some stunning moments of skill and defence-spilitting passes. Netted the winner in last week's victory over Bournemouth as Spurs picked up their first home league win of the season.
HARRY KANE (Tottenham): The fact that speculation regarding a potential move away from Tottenham continues to grow just highlights the quality of Kane's all-round displays as well as his 11 goals at club level so far this campaign. The best natural finisher in the Premier League, he is closing in on Europe's very best almost by the week.
MOHAMED SALAH (Liverpool): Given Sadio Mane's absence, his role in the Liverpool team has become even more important as he adds some much-needed pace to their attacking play. Has already scored eight goals in all competitions since his arrival from Roma and has formed a great understanding with Roberto Firmino.
Have we got it right? Is there someone missing from our XI that deserves a place? Have your say in the comments below!