That result at Upton Park has piled severe pressure on Slaven Bilic, who is available at 11/2 (6.50) with dabblebet to ease the doubts over his future by masterminding an impressive victory here.
In contrast, Spurs ran out impressive 4-1 winners over Liverpool on Sunday to move level on points with second-placed Manchester United, and are clear 1/2 (1.50) favourites to build on that result with another victory in this one.
Just one of the last 12 encounters between these sides has resulted in a draw, but there are odds of 7/2 (4.50) on offer on them taking this game into extra-time with a stalemate after 90 minutes.
Already under scrutiny following an unconvincing start to the campaign, the chastening home defeat against newly-promoted Brighton has reportedly left Bilic just two games to save himself from the sack.
Considering the second of those two matches is a trip to Selhurst Park to take on fellow strugglers Crystal Palace, it would be understandable should the Croatian boss choose to prioritise that potential relegation six-pointer over this daunting cup clash.
With eight wins and no defeats to their name in the last 11 fixtures, Mauricio Pochettino’s men are probably behind only Premier League leaders Manchester City as the form team in the country.
Having scored 13 goals and conceded just two in the most recent five matches, Pochettino’s team should prove far too good for an understrength West Ham side that has let in 11 goals and only scored twice in five away games versus top flight opposition this season.
With this in mind, odds of 23/20 (2.15) seem rather generous on high-flying Tottenham winning by at least two clear goals against their out-of-sorts rivals here.